Dietary α-Tocopherol Decreases α-Tocotrienol but Not γ-Tocotrienol Concentration in Rats
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چکیده
منابع مشابه
δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.
The cancer preventive activity of vitamin E has been extensively discussed, but the activities of specific forms of tocopherols have not received sufficient attention. Herein, we compared the activities of δ-tocopherol (δ-T), γ-T, and α-T in a colon carcinogenesis model. Male F344 rats, seven weeks old, were given two weekly subcutaneous injections of azoxymethane (AOM) each at a dose of 15 mg/...
متن کاملγ-Tocopherol, but not α-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats
Insulin resistance may enhance the neointima formation via increased oxidative stress. However, clinical trials investigating the benefit of antioxidant therapy with α-tocopherol showed negative results. Recent studies showed that chemical characteristics of γ-tocopherol are distinct from those of α-tocopherol. We hypothesized that γ-tocopherol is superior to α-tocopherol in preventing the neoi...
متن کاملTissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
We previously found that 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (γCEHC), a metabolite of the vitamin E isoforms γ-tocopherol or γ-tocotrienol, accumulated in the rat small intestine. The aim of this study was to evaluate tissue distribution of vitamin E metabolites. A single dose of α-tocopherol, γ-tocopherol or a tocotrienol mixture containing α- and γ-tocotrienol was orally admin...
متن کاملEffects of tocotrienol on tumor necrosis factor-α/d-galactosamine-induced steatohepatitis in rats
It has been reported that α-tocopherol (α-Toc), a vitamin E analog, is effective for treatment of non-alcoholic steatohepatitis (NASH). However, it is unknown whether or not other vitamin E analogs are effective. Therefore we designed a new rat model of steatohepatitis induced by tumor necrosis factor-α (TNF-α) stimulation, and used it to investigate the effects of vitamin E analogs. The rat li...
متن کاملLocation of α-tocopherol and α-tocotrienol to heterogeneous cell membranes and inhibition of production of peroxidized cholesterol in mouse fibroblasts
BACKGROUND α-Tocopherol (α-T) and α-tocotrienol (α-T3) are well recognized as lipophilic antioxidants. Nevertheless, there is limited knowledge on their location in heterogeneous cell membranes. We first investigated the distribution of α-T and α-T3 to the cholesterol-rich microdomains (lipid rafts and caveolae) of heterogeneous cell membranes by incubating these antioxidants with cultured mous...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2003
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/133.2.428